Correcting for cryptic relatedness by a regression-based genomic control method
نویسندگان
چکیده
منابع مشابه
Correcting for Cryptic Relatedness in Genome-Wide Association Studies
While the individuals chosen for a genome-wide association study (GWAS) may not be closely related to each other, there can be distant (cryptic) relationships that confound the evidence of disease association. These cryptic relationships violate the GWAS assumption regarding the independence of the subjects’ genomes, and failure to account for these relationships results in both false positives...
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Cryptic relatedness was suggested to be an important source of confounding in population-based association studies (PBAS). The magnitude and manner of cryptic relatedness affecting the performance of PBAS of continuous traits remain to be investigated. We simulated a set of related samples through biased sampling and inbreeding, and evaluated the power and type I error rates of simple associati...
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Case-control association studies are widely used in the search for genetic variants that contribute to human diseases. It has long been known that such studies may suffer from high rates of false positives if there is unrecognized population structure. It is perhaps less widely appreciated that so-called "cryptic relatedness" (i.e., kinship among the cases or controls that is not known to the i...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2009
ISSN: 1471-2156
DOI: 10.1186/1471-2156-10-78